Background: Acid phosphatase is a phosphomono-esterase enzyme stored in lysosomes, it has an acid pH optimum, the highest serum activity of acid phosphatase found in metastasized prostate cancer, diseases of the bone , hyper-para- thyroidism, diseases of blood cells , multiple myeloma , lysosomal storage diseases, systemic infection, anemia, thrombo-phlebitis, kidney disease, liver disease, heart attack and oxidative stress conditions. Cigarette smoke contains a large number of oxidative compounds, zinc is postulated to influence oxidants vie its role as a cofactor for Cu,Zn-SOD enzyme , increase zinc intake raises plasma and Erythrocyte SOD.
Objectives: The present investigation is an attempt to study the effect of cigarette smoking and zinc supplementation on serum activity of Acid phosphatase enzyme in cigarette smoker subjects.
Subjects and Methodology: serum activity of Acid phosphatase enzyme was evaluated in 10 male smoker subjects before and after zinc supplementation.
Results: Acid phosphatase enzyme serum activity was higher in smokers group before zinc supplementation (Mean ± SD)=( 2.9646 ± 1.0154) U/L than in control group (Mean ±
SD)=( 2.0135 ± 0.5789)U/L P. Value was 0.037 significant, Acid phosphatase enzyme serum activity decreased in smokers group after zinc supplementation (Mean ± SD)=( 1.721 ± 0.84994)U/L in comparison to smokers group before zinc supplementation (Mean ± SD)= (2.9646 ± 1.0154) U/L P. Value was 0.007 significant.
Conclusion: a tissue cells injury in smoker subjects appeared as an increase in serum activity of ACP enzyme but with zinc supplementation the improving of tissue cells in smoker subjects appeared as a decreased in serum activity of ACP enzyme.