This study was done  to determine the level of blood glucose and activities of liver enzymes; aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase(ALP) in  patients with malaria. 100  confirmed malaria patients their  age ranged between  10 – 20 years  attending General Hospital  Owerri were selected  for the  study.100 normal  subjects age 10  - 20 years free from malaria  were used  as a control group. Patients  with infections, catarrh and cough were excluded. The result showed that the blood glucose level  significantly decreased  (3.86 ± 0.15mmol/l) P. value < 0.05 in  malaria  subjects when  compared  with  the  control (5.68 ± 0.27mmol/l). Serum activities of aspartate aminotransferase (29.90 ± 5.82iu/l) and alanine aminotransferase (19.64 ± 3.11iu/l)  were significantly higher  P