Abstract:

Lead is a natural element and widespread in the environment, lead poisoning may affect numerous organ systems and is associated with a number of morphological, biochemical and physiological changes, including kidney dysfunction, abnormal glucose metabolism, nervous system disturbances, impairment of liver function and hematological disorders, lead-induced oxidative stress contributes to the pathogenesis of lead poisoning for disrupting the delicate pro-oxidant/antioxidant balance that exists within mammalian cells.

Objectives: to assess the risk  that may results from exposure to two different doses of lead acetate on   liver and kidney functions. Materials and Methods:

6 Female  rabbit divided into three groups, one group received 0.9 mg/kg b.w lead acetate in the drinking water , Another group received 0.6 mg/kg b.w lead acetate in the drinking water , the third group received drinking water that contain sodium acetate 0.9 mg/kg b.w served as control group daily, after 3  weeks the rabbits of all groups were scarified and blood was drawn .

Serum from all samples were subjected to the following tests: measurement of ALT , AST serum activity, urea and creatinine serum level .